Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.64 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | KDM1A | O60341 | 2/20 | 0.54 |
| ▸ | CTRC | Q99895 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565700 | 1.00 | MAPT (0.68) | MAPTALDH1A1HPGDGAAITGA4 | |
| SCHEMBL9129353 | 0.81 | SIRT1 (0.57) | MAPTALDH1A1HPGDGAAEGFR | |
| SCHEMBL9129357 | 0.81 | SIRT1 (0.57) | MAPTALDH1A1HPGDGAAEGFR | |
| SCHEMBL8539935 | 0.81 | MAPT (0.57) | MAPTALDH1A1HPGDGAAEGFR | |
| SCHEMBL5472251 | 0.75 | ERBB2 (1.00) | MAPTALDH1A1HPGDEGFRERBB2 | |
| SCHEMBL5472252 | 0.75 | ERBB2 (1.00) | MAPTALDH1A1HPGDEGFRERBB2 | |
| SCHEMBL13045105 | 0.75 | GAA (0.75) | ALDH1A1GAAEGFRERBB2IGF1R | |
| SCHEMBL9565715 | 0.74 | MEN1 (0.55) | MAPTALDH1A1HPGDGAAEGFR | |
| SCHEMBL9565714 | 0.74 | MEN1 (0.55) | MAPTALDH1A1HPGDGAAEGFR | |
| SCHEMBL9565698 | 0.74 | EEF2K (0.52) | MAPTALDH1A1GAAEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546661-A1 | Pyrimidine derivatives, method for preparation thereof and pharmaceutical composition having said derivatives as active elements | JAPAN ENERGY CORPORATION (JP) | 1993-06-16 | — | — | EP | disclosed |