Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29497318 | 0.83 | HTR7 (0.39) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL1863318 | 0.83 | HTR7 (0.39) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL9562554 | 0.82 | HTR7 (0.38) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL29473303 | 0.73 | HTR7 (0.42) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL11773796 | 0.73 | HTR7 (0.42) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| Bromide SCHEMBL9718079 | 0.73 | ATM (0.35) | ADRA2AADRA2BADRA2CATMLMNA | |
| SCHEMBL15353596 | 0.72 | HTR1A (0.45) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL10412062 | 0.71 | HTR7 (0.41) | HTR1AADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL30556213 | 0.71 | CA1 (0.38) | ADRA2BSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL9566318 | 0.70 | TAAR1 (0.39) | KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544287-A1 | Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E.R. SQUIBB & SONS, INC. (US) | 1993-06-02 | — | — | EP | disclosed |