Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413034 | 0.89 | HDAC1 (0.56) | SMN1; SMN2F2TSHRHDAC1HDAC3 | |
| SCHEMBL9566506 | 0.88 | HDAC1 (0.60) | SMN1; SMN2CYP11B1CYP11B2PTGS2HDAC1 | |
| SCHEMBL9566608 | 0.87 | NPC1 (0.58) | SMN1; SMN2KCNMA1HDAC1HDAC3HDAC2 | |
| SCHEMBL9566631 | 0.87 | MEN1 (0.56) | SMN1; SMN2KCNMA1TSHRHDAC1HDAC3 | |
| SCHEMBL11591085 | 0.85 | HDAC1 (0.60) | SMN1; SMN2HDAC1HDAC3HDAC2KMT2A | |
| SCHEMBL11591466 | 0.85 | HDAC1 (0.60) | SMN1; SMN2HDAC1HDAC3HDAC2KMT2A | |
| SCHEMBL9566577 | 0.84 | NPC1 (0.54) | SMN1; SMN2KCNMA1TSHRKMT2AMEN1 | |
| SCHEMBL10483482 | 0.84 | MEN1 (0.55) | SMN1; SMN2KCNMA1HDAC1HDAC3HDAC2 | |
| SCHEMBL10483348 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2HDAC1HDAC3HDAC2KMT2A | |
| SCHEMBL9566558 | 0.83 | NPC1 (0.49) | SMN1; SMN2KCNMA1HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| EP-0563386-A1 | ANTICANCER COMPOSITION AND COMPOUND | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-10-06 | — | — | EP | disclosed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |