Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566457 | 0.87 | SMN1; SMN2 (0.55) | NPC1RAB9AABL1HDAC1HDAC3 | |
| SCHEMBL9566528 | 0.87 | NPC1 (0.56) | NPC1RAB9AABL1HDAC1HDAC3 | |
| SCHEMBL9566631 | 0.87 | MEN1 (0.56) | NPC1RAB9AABL1HDAC1HDAC3 | |
| SCHEMBL10483348 | 0.85 | SMN1; SMN2 (0.59) | NPC1RAB9AHDAC1HDAC3HDAC2 | |
| SCHEMBL8413034 | 0.83 | HDAC1 (0.56) | NPC1RAB9AHDAC1HDAC3HDAC2 | |
| SCHEMBL9566577 | 0.83 | NPC1 (0.54) | NPC1RAB9AALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9566506 | 0.83 | HDAC1 (0.60) | NPC1RAB9AHDAC1HDAC3HDAC2 | |
| SCHEMBL9566558 | 0.83 | NPC1 (0.49) | NPC1RAB9AHDAC1HDAC3HDAC2 | |
| SCHEMBL9566519 | 0.83 | AAK1 (0.55) | NPC1RAB9AALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL9566451 | 0.82 | SMN1; SMN2 (0.56) | NPC1RAB9AHDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | claimed |
| EP-0563386-A1 | ANTICANCER COMPOSITION AND COMPOUND | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-10-06 | — | — | EP | disclosed |
| US-4874762-A | TREATING DEMENTIA | NIPPON SHINYAKU CO., LTD. (JP) | 1989-10-17 | — | — | US | disclosed |