Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12020926 | 0.88 | MAPT (0.56) | MEN1TSHRKMT2AMAPTKCNK3 | |
| SCHEMBL9566838 | 0.88 | MAPT (0.56) | MEN1TSHRKMT2AMAPTRXFP1 | |
| SCHEMBL9566885 | 0.87 | MAPT (0.54) | MEN1TSHRKMT2AMAPTRXFP1 | |
| SCHEMBL9566750 | 0.87 | MEN1 (0.54) | MEN1TSHRKMT2AMAPTKCNK3 | |
| SCHEMBL9566781 | 0.86 | MEN1 (0.61) | MEN1TSHRKMT2AMAPTRXFP1 | |
| SCHEMBL9566801 | 0.84 | MAPT (0.56) | MEN1TSHRKMT2AMAPTRXFP1 | |
| SCHEMBL9566901 | 0.83 | KMT2A (0.62) | MEN1TSHRKMT2AMAPTKCNK3 | |
| SCHEMBL12020443 | 0.80 | NPC1 (0.51) | MEN1TSHRKMT2AMAPTRXFP1 | |
| SCHEMBL4683413 | 0.78 | KCNK3 (0.88) | MEN1TSHRKMT2AMAPTKCNK3 | |
| SCHEMBL9566799 | 0.77 | CXCR2 (0.53) | MEN1KMT2ARXFP1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |