Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL956304 | 0.84 | CXCR2 (0.72) | CXCR2 | |
| SCHEMBL958516 | 0.84 | CXCR2 (0.54) | CXCR2 | |
| SCHEMBL956581 | 0.84 | CXCR2 (0.57) | CXCR2 | |
| SCHEMBL957633 | 0.83 | CXCR2 (0.52) | CXCR2 | |
| SCHEMBL954899 | 0.81 | CXCR2 (0.54) | CXCR2 | |
| SCHEMBL956296 | 0.80 | CXCR2 (0.56) | CXCR2 | |
| SCHEMBL959607 | 0.79 | CXCR2 (0.50) | CXCR2 | |
| SCHEMBL959605 | 0.79 | CXCR2 (0.50) | CXCR2 | |
| SCHEMBL954898 | 0.78 | CXCR2 (0.49) | CXCR2 | |
| SCHEMBL30515692 | 0.78 | CXCR2 (0.49) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009429-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | NOVARTIS AG (CH) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009429-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | CXCR2, CXCR1, CXCR3 | CXCR2 1/4885CHRM5 1809/4885CX3CR1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.