SCHEMBL954898

SCHEMBL954898

Oc1cc(CCc2cccc(F)c2F)nc2cc(-c3ccco3)nn12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 3/20 0.49
ADORA2A P29274 4/20 0.38
ADORA2B P29275 3/20 0.38
ADORA1 P30542 3/20 0.38
ADORA3 P0DMS8 2/20 0.38
ABCB1 P08183 4/20 0.38
FUBP1 Q96AE4 1/20 0.37
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 2/20 0.36
NPC1 O15118 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
BLM P54132 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.36
ALOX15 P16050 1/20 0.36
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
DPP4 P27487 1/20 0.36
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30515692 1.00 CXCR2 (0.49) CXCR2ADORA2AADORA2BADORA1ADORA3
SCHEMBL3343769 0.85 CXCR2 (0.56) CXCR2ALDH1A1KDM4ENPC1MAPK1
SCHEMBL956569 0.83 ABCB1 (0.41) ADORA2AADORA2BADORA1ADORA3ABCB1
SCHEMBL954341 0.83 ABCB1 (0.43) ADORA2AADORA2BADORA1ADORA3ABCB1
SCHEMBL956154 0.83 FFAR1 (0.40) CXCR2ADORA2AABCB1FUBP1ALDH1A1
SCHEMBL958516 0.82 CXCR2 (0.54) CXCR2ADORA2AADORA2BADORA1ADORA3
SCHEMBL956372 0.81 FUBP1 (0.39) ABCB1FUBP1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL22390007 0.80 CXCR2 (0.42) CXCR2ADORA2AADORA2BADORA1ADORA3
SCHEMBL956581 0.80 CXCR2 (0.57) CXCR2ALDH1A1KDM4EMEN1ALOX15
SCHEMBL956304 0.80 CXCR2 (0.72) CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-10660909-B2 Method for treating cancer using chemokine antagonists SYNTRIX BIOSYSTEMS INC. (US) 2020-05-26 US disclosed
WO-2019055509-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. (US) 2019-03-21 WO disclosed
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-23 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-06-28 US disclosed
WO-2017156270-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. (US) 2017-09-14 WO disclosed
US-20110009429-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 NOVARTIS AG (CH) 2011-01-13 US disclosed
EP-2257552-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 Novartis AG (CH) 2010-12-08 EP disclosed
WO-2009106539-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 NOVARTIS AG (CH) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885ADORA2A 337/4885ADORA2B 1497/4885
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885ADORA2A 1117/4885ADORA2B 3540/4885
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders CXCR1, CXCR2, CXCR6 CXCR2 2/4885ADORA2A 330/4885ADORA2B 1313/4885
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF CXCR1, CXCR2, FPR2 CXCR2 2/4885ADORA2A 1156/4885ADORA2B 2786/4885
US-20180177808-A1 METHOD FOR TREATING CANCER USING CHEMOKINE ANTAGONISTS CXCR1, CXCR2, CXCR5 CXCR2 2/4885ADORA2A 159/4885ADORA2B 636/4885
US-20110009429-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 CXCR2, CXCR1, CXCR3 CXCR2 1/4885ADORA2A 279/4885ADORA2B 316/4885
US-10660909-B2 Method for treating cancer using chemokine antagonists CXCR1, CXCR2, CXCR5 CXCR2 2/4885ADORA2A 159/4885ADORA2B 636/4885
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CXCR2 2/4885ADORA2A 1117/4885ADORA2B 3540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.