Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 7/20 | 0.43 |
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | FYN | P06241 | 5/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19730198 | 0.84 | FGFR1 (0.49) | FGFR1FGFR4ALDH1A1SCN9A | |
| SCHEMBL16888474 | 0.81 | ABL1 (0.49) | FGFR1FGFR4LMNAMAPTTHRB | |
| SCHEMBL29246282 | 0.79 | FGFR1 (0.56) | FGFR1FGFR4HRH3MAPTTHRB | |
| SCHEMBL30910343 | 0.79 | FGFR1 (0.56) | FGFR1FGFR4HRH3MAPTTHRB | |
| SCHEMBL957705 | 0.76 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2MAPTTHRBDBH | |
| SCHEMBL9278020 | 0.74 | TP53 (0.45) | LMNASMN1; SMN2MAPTSRCFLT3 | |
| SCHEMBL2038788 | 0.72 | FGFR1 (0.39) | FGFR1FGFR4SMN1; SMN2ALDH1A1 | |
| SCHEMBL31240654 | 0.72 | FGFR1 (0.39) | FGFR1FGFR4SMN1; SMN2ALDH1A1 | |
| SCHEMBL6085877 | 0.72 | HTR6 (0.53) | LMNASMN1; SMN2MAPTTHRBDBH | |
| SCHEMBL22533570 | 0.71 | FGFR1 (0.44) | FGFR1FGFR4HRH3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450343-B2 | Gamma secretase modulators | SCHERING CORPORATION | 2013-05-28 | — | — | US | disclosed |
| US-8450343-B2 | Gamma secretase modulators | SCHERING CORPORATION | 2013-05-28 | — | — | US | disclosed |
| US-8450343-B2 | Gamma secretase modulators | SCHERING CORPORATION | 2013-05-28 | — | — | US | disclosed |
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-01-20 | — | — | US | disclosed |
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-01-20 | — | — | US | disclosed |
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-01-20 | — | — | US | disclosed |
| CN-101939315-A | Gamma secretase modulators | SCHERING CORP | 2011-01-05 | — | — | CN | disclosed |
| EP-2229381-A1 | GAMMA SECRETASE MODULATORS | Schering Corporation (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009073777-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015190-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | FGFR1 2737/4885FGFR4 2900/4885HRH3 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.