Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CBLB | Q13191 | 11/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952892 | 0.84 | LMNA (0.64) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL943582 | 0.82 | LMNA (0.63) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL944106 | 0.80 | LMNA (0.60) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL12857536 | 0.79 | SMN1; SMN2 (0.64) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL946100 | 0.78 | LMNA (0.56) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL14672846 | 0.78 | LMNA (0.49) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL17680694 | 0.78 | SMN1; SMN2 (0.63) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL22368582 | 0.77 | LMNA (0.61) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL14672844 | 0.77 | LMNA (0.52) | LMNAGAACLK1SMN1; SMN2CBLB | |
| SCHEMBL945106 | 0.76 | LMNA (0.56) | LMNAGAACLK1SMN1; SMN2CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |