Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CBLB | Q13191 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944106 | 0.90 | LMNA (0.60) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL943582 | 0.88 | LMNA (0.63) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL943901 | 0.85 | LMNA (0.60) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL952626 | 0.84 | MAP3K5 (0.67) | LMNAGAACBLBSMN1; SMN2GRM4 | |
| SCHEMBL956896 | 0.84 | LMNA (0.65) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL946100 | 0.84 | LMNA (0.56) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL946006 | 0.83 | LMNA (0.56) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL12857536 | 0.82 | SMN1; SMN2 (0.64) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL14672844 | 0.82 | LMNA (0.52) | LMNAGAACBLBSMN1; SMN2CLK1 | |
| SCHEMBL945106 | 0.82 | LMNA (0.56) | LMNAGAACBLBSMN1; SMN2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |