Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 10/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 12/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569169 | 0.83 | TOP1 (0.51) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL9388538 | 0.81 | TOP1 (0.54) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL9569160 | 0.80 | TOP1 (0.48) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL9569139 | 0.77 | TOP1 (0.51) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL14668818 | 0.74 | STAT3 (0.55) | TOP1PIM1KDM4EALDH1A1 | |
| SCHEMBL9560449 | 0.74 | TOP1 (0.39) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL9569173 | 0.71 | STAT3 (0.39) | TOP1TOP2ATOP2B | |
| SCHEMBL10918713 | 0.70 | TOP1 (0.53) | TOP1KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL9513066 | 0.70 | TOP2A (0.59) | TOP1KDM4EALDH1A1POLBTOP2A | |
| SCHEMBL9460937 | 0.70 | STAT3 (0.57) | TOP1PIM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563734-A1 | 9-fluoro-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acids and esters and their use as antiviral agents | BAYER AG (DE) | 1993-10-06 | — | — | EP | disclosed |