Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
| ▸ | PGK2 | P07205 | 1/20 | 0.42 |
| ▸ | ADA | P00813 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8824287 | 0.86 | ADORA2A (0.59) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569388 | 0.86 | SLC29A1 (0.51) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL8824300 | 0.86 | ADORA2A (0.59) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569320 | 0.84 | ADORA2A (0.49) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569353 | 0.84 | ADORA2A (0.52) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL8713052 | 0.84 | ADORA2A (0.54) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569344 | 0.82 | ADORA2A (0.50) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL14045433 | 0.82 | PGK1 (0.54) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569345 | 0.82 | ADORA3 (0.51) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 | |
| SCHEMBL9569366 | 0.81 | ADORA3 (0.66) | ADORA2ASLC29A1PDE4DPDE3ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576227-A2 | 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | claimed |
| EP-0576227-A2 | 2'-Deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |