Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955472 | 0.86 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL9936013 | 0.86 | METAP2 (0.44) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL6485 | 0.83 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL30884953 | 0.83 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL29208955 | 0.83 | METAP2 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL10852261 | 0.82 | METAP2 (0.39) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL7073073 | 0.80 | RAD52 (0.42) | METAP2METAP1NPY5RENPP1ITGB3 | |
| SCHEMBL7851163 | 0.80 | PI4KA (0.49) | METAP2METAP1NPY5RPI4KAPI4K2B | |
| SCHEMBL3691689 | 0.79 | PI4KA (0.55) | METAP2METAP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL5062499 | 0.79 | METAP2 (0.39) | METAP2METAP1NPY5RPI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |