Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571014 | 0.86 | PARP1 (0.38) | PARP1DAOALOX15CXCR1CXCR2 | |
| SCHEMBL9571043 | 0.77 | MAPT (0.40) | PARP1DAOGPR84KDM4EMAPT | |
| SCHEMBL9337517 | 0.76 | KDM4E (0.45) | PARP1DAOPTGS1PTGS2LMNA | |
| SCHEMBL24881442 | 0.73 | PABPC1 (0.47) | PARP1DAOGPR84KDM4E | |
| SCHEMBL9341344 | 0.72 | KDM4E (0.57) | PARP1DAOLMNATSHRKDM4E | |
| SCHEMBL14012132 | 0.69 | KDM4E (0.41) | PARP1DAOALOX15PTGS1PTGS2 | |
| SCHEMBL3071416 | 0.69 | HSD17B2 (0.34) | — | |
| SCHEMBL13327029 | 0.69 | DAO (0.41) | PARP1DAOPTGS1PTGS2LMNA | |
| SCHEMBL15798590 | 0.67 | PARP1 (0.40) | PARP1PTGS1PTGS2LMNABLM | |
| SCHEMBL28396369 | 0.67 | GABRA1 (0.46) | TSHRPOLBKDM4EKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |