Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 17/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 17/20 | 0.63 |
| ▸ | CDK2 | P24941 | 17/20 | 0.63 |
| ▸ | CDK4 | P11802 | 10/20 | 0.63 |
| ▸ | CCND1 | P24385 | 10/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.63 |
| ▸ | CDK1 | P06493 | 9/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.63 |
| ▸ | CCND3 | P30281 | 5/20 | 0.60 |
| ▸ | CCND2 | P30279 | 3/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958320 | 0.83 | FBP1 (0.64) | CCNE2CCNE1CDK2FBP1 | |
| SCHEMBL10111964 | 0.81 | CCNE2 (0.80) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4734684 | 0.76 | CCNE2 (1.00) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL5213503 | 0.75 | CCNE2 (1.00) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL25008210 | 0.75 | CDK2 (1.00) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL3467435 | 0.75 | CCNE2 (0.72) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4211318 | 0.75 | CDK2 (0.67) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4207829 | 0.75 | CDK2 (0.67) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4211315 | 0.75 | CDK2 (0.67) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4207834 | 0.75 | CDK2 (0.67) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868030-B2 | FBPase inhibitors for diabetes | HOFFMANN-LA ROCHE INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-2032548-A1 | THIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | claimed |
| WO-2007137962-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-06 | — | — | WO | claimed |
| US-20070281979-A1 | Fructose-1,6-bisphosphatase (FBPase) inhibitors, such as N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]3(difluoromethoxy)benzenesulfonamide, used as antidiabetic agents | HOFFMANN-LA ROCHE INC. | 2007-12-06 | — | — | US | claimed |
| US-7868030-B2 | FBPase inhibitors for diabetes | HOFFMANN-LA ROCHE INC. (US) | 2011-01-11 | — | — | US | disclosed |
| EP-2032548-A1 | THIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137962-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-06 | — | — | WO | disclosed |
| US-20070281979-A1 | Fructose-1,6-bisphosphatase (FBPase) inhibitors, such as N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]3(difluoromethoxy)benzenesulfonamide, used as antidiabetic agents | HOFFMANN-LA ROCHE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281979-A1 | Fructose-1,6-bisphosphatase (FBPase) inhibitors, such as N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]3(difluoromethoxy)benzenesulfonamide, used as antidiabetic agents | FBP1, PFKFB1, PFKFB3 | CCNE2 1513/4885CCNE1 659/4885CDK2 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.