Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764497 | 1.00 | TDP1 (0.55) | TDP1L3MBTL1CALM1TAAR1NPC1 | |
| SCHEMBL7230240 | 0.98 | TDP1 (0.53) | TDP1L3MBTL1CALM1TAAR1NPC1 | |
| SCHEMBL9574168 | 0.93 | TDP1 (0.59) | TDP1L3MBTL1CALM1TAAR1MAOB | |
| SCHEMBL9574323 | 0.93 | TDP1 (0.63) | TDP1L3MBTL1CALM1TAAR1SMN1; SMN2 | |
| SCHEMBL7228686 | 0.93 | TDP1 (0.50) | TDP1L3MBTL1CALM1TAAR1NPC1 | |
| SCHEMBL4027553 | 0.86 | TAAR1 (0.52) | TDP1L3MBTL1CALM1TAAR1NPC1 | |
| SCHEMBL1355360 | 0.85 | L3MBTL1 (0.65) | TDP1L3MBTL1CALM1NPC1RAB9A | |
| SCHEMBL27089918 | 0.85 | L3MBTL1 (0.65) | TDP1L3MBTL1CALM1NPC1RAB9A | |
| SCHEMBL16727734 | 0.85 | L3MBTL1 (0.65) | TDP1L3MBTL1CALM1NPC1RAB9A | |
| SCHEMBL6682756 | 0.84 | CALM1 (0.58) | TDP1L3MBTL1CALM1TAAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243076-A | Adrenergic stimulant intermediates | GLAXO GROUP LTD. | 1993-09-07 | — | — | US | disclosed |
| US-5225445-A | Respiratory system disorders | GLAXO GROUP LTD. | 1993-07-06 | — | — | US | disclosed |
| US-5126375-A | Asthma, chronic bronchitis | GLAXO GROUP LTD. (GB) | 1992-06-30 | — | — | US | disclosed |
| US-5091422-A | Treating inflammatory or allergic skin disease, lowering gastric acidity | GLAXO GROUP LIMITED (GB) | 1992-02-25 | — | — | US | disclosed |
| US-4992474-A | Adrenergic stimulants | GLAXO GROUP LTD. (GB) | 1991-02-12 | — | — | US | disclosed |
| US-4853381-A | Ethanolamine compounds | GLAXO GROUP LIMITED (GB) | 1989-08-01 | — | — | US | disclosed |
| EP-0162576-B1 | ETHANOLAMINE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1989-07-26 | — | — | EP | disclosed |
| EP-0162576-A1 | Ethanolamine compounds | GLAXO GROUP LIMITED (GB) | 1985-11-27 | — | — | EP | disclosed |