Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.55 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.55 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.55 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.55 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19241181 | 0.91 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL25229650 | 0.91 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL10477783 | 0.91 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL23042348 | 0.91 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL27166293 | 0.91 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL16236223 | 0.90 | LMNA (0.66) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL15096661 | 0.88 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL6368636 | 0.88 | KDM4E (0.59) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL12554987 | 0.88 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL12554333 | 0.88 | LMNA (0.69) | KDM4EDUSP3MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187293-A | Blood platelet activating factor inhibitors | HOFFMANN-LA ROCHE INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-4731373-A | BLOOD PLATELET ACTIVATING FACTOR | HOFFMAN-LA ROCHE INC. (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0147768-A2 | Glycerin derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-10 | — | — | EP | disclosed |