Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9576238 | 0.93 | HCAR2 (0.50) | TSHRALDH1A1USP2HPGDCYP3A4 | |
| SCHEMBL19185258 | 0.84 | TSHR (0.68) | TSHRALDH1A1USP2HPGDCYP3A4 | |
| SCHEMBL9719220 | 0.82 | TSHR (0.44) | TSHRALDH1A1USP2HPGDCYP3A4 | |
| SCHEMBL11749700 | 0.81 | TSHR (0.47) | TSHRALDH1A1HPGDHCAR2ATM | |
| SCHEMBL15355365 | 0.81 | TSHR (0.47) | TSHRALDH1A1HPGDHCAR2ATM | |
| SCHEMBL11748242 | 0.81 | TSHR (0.47) | TSHRALDH1A1HPGDHCAR2ATM | |
| SCHEMBL317108 | 0.80 | TSHR (0.67) | TSHRALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL429885 | 0.80 | TSHR (0.67) | TSHRALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL317107 | 0.80 | TSHR (0.67) | TSHRALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL11050380 | 0.78 | HCAR2 (0.45) | TSHRALDH1A1USP2HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219884-B1 | HARD CONTACT LENS MATERIAL | Tomei Sangyo Kabushiki Kaisha (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-5142009-A | Crosslinked blend of fumaric acid diesters | TOMEI SANGYO KABUSHIKI KAISHA (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4868260-A | OXYGEN PERMEABILITY | TOMEI SANGYO KABUSHIKI KAISHA (JP) | 1989-09-19 | — | — | US | disclosed |
| EP-0219884-A2 | Hard contact lens material | Tomei Sangyo Kabushiki Kaisha (JP) | 1987-04-29 | — | — | EP | disclosed |