Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958047 | 1.00 | HSD11B1 (0.81) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL958048 | 1.00 | HSD11B1 (0.81) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL957992 | 0.91 | HSD11B1 (0.80) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL957990 | 0.91 | HSD11B1 (0.80) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL736259 | 0.91 | HSD11B1 (0.80) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL116687 | 0.90 | HSD11B1 (1.00) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL956594 | 0.90 | HSD11B1 (0.82) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL956596 | 0.90 | HSD11B1 (0.82) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL116688 | 0.90 | HSD11B1 (1.00) | HSD11B1CYP3A4CYP2C9KCNH2CYP2C19 | |
| SCHEMBL960127 | 0.89 | HSD11B1 (0.80) | HSD11B1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8575156-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575156-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575156-B2 | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110015157-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals ,Inc. | 2011-01-20 | — | — | US | disclosed |
| EP-2183228-A1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009017664-A1 | CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009017664-A1 | CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015157-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885CYP3A4 272/4885CYP2C9 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.