Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581497 | 0.87 | TDP1 (0.65) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9581782 | 0.85 | TDP1 (0.61) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9582591 | 0.85 | TDP1 (0.59) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9581622 | 0.84 | TDP1 (0.63) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9582281 | 0.84 | DRD2 (0.48) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9581329 | 0.83 | HTR1A (0.59) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL6437727 | 0.82 | PARP1 (0.66) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9582081 | 0.81 | TDP1 (0.56) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9581522 | 0.81 | TDP1 (0.59) | TDP1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9581698 | 0.81 | TDP1 (0.69) | TDP1HTR1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |