Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211409 | 0.80 | ACHE (1.00) | ACHE | |
| SCHEMBL9583346 | 0.79 | ACHE (0.57) | ACHE | |
| SCHEMBL9583434 | 0.78 | ACHE (0.55) | ACHE | |
| SCHEMBL9583223 | 0.78 | ACHE (0.55) | ACHEALDH1A1CYP1A2 | |
| SCHEMBL9583737 | 0.70 | ACHE (1.00) | ACHEALDH1A1CYP1A2 | |
| SCHEMBL9583526 | 0.67 | ACHE (1.00) | ACHEALDH1A1CYP1A2ELANE | |
| SCHEMBL9215322 | 0.62 | ACHE (1.00) | ACHEALDH1A1CYP1A2TP53 | |
| SCHEMBL14616764 | 0.61 | ACHE (0.45) | ACHETP53SMN1; SMN2 | |
| SCHEMBL28346270 | 0.60 | ACHE (0.35) | ACHE | |
| SCHEMBL12963984 | 0.59 | ACHE (0.40) | ACHEALDH1A1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002739-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |