Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 1.00 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9583737 | 0.84 | ACHE (1.00) | ACHEALDH1A1CYP1A2BCHEGRIN1 | |
| SCHEMBL9211409 | 0.80 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL9039832 | 0.79 | ACHE (1.00) | ACHEALDH1A1CYP1A2KDM4ECYP2D6 | |
| SCHEMBL9215322 | 0.74 | ACHE (1.00) | ACHEALDH1A1CYP1A2KDM4ECYP2D6 | |
| SCHEMBL10653196 | 0.70 | ACHE (0.70) | ACHEDCPSALDH1A1KDM4EHPGD | |
| SCHEMBL7283298 | 0.68 | ACHE (0.56) | ACHEDCPSALDH1A1CYP1A2KDM4E | |
| SCHEMBL9584331 | 0.68 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL28984974 | 0.68 | ACHE (0.66) | ACHEDCPSALDH1A1KDM4EHPGD | |
| SCHEMBL11057340 | 0.67 | DCPS (0.57) | ACHEDCPSALDH1A1CYP1A2KDM4E | |
| SCHEMBL9583926 | 0.67 | ACHE (0.67) | ACHEALDH1A1CYP1A2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202440-A | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines | PFIZER INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0311303-A2 | 4-aminopyridine derivatives | PFIZER INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| WO-1989002740-A1 | 4-AMINOPYRIDINE DERIVATIVES | PFIZER INC. (US) | 1989-04-06 | — | — | WO | disclosed |