Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alosetron SCHEMBL148316 | 0.77 | HTR2A (0.74) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| Alosetron SCHEMBL311317 | 0.77 | CASP6 (0.74) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| Alosetron SCHEMBL7371660 | 0.77 | CASP6 (0.74) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| SCHEMBL9586260 | 0.76 | KCNH2 (0.44) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| SCHEMBL20027463 | 0.76 | KCNH2 (0.57) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| SCHEMBL20022665 | 0.75 | HTR2A (0.56) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| SCHEMBL3321223 | 0.75 | KCNH2 (0.54) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| Alosetron SCHEMBL2229995 | 0.72 | KCNH2 (0.65) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| SCHEMBL9090028 | 0.71 | CYP1A2 (0.64) | HTR2AADRA2CHTR2CADRA1AHTR2B | |
| Alosetron SCHEMBL18452338 | 0.70 | KCNH2 (0.54) | HTR2AADRA2CHTR2CADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223625-A | Antagonistic acitivity on 5-hydroxytryptamine receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1993-06-29 | — | — | US | disclosed |