Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585706 | 1.00 | HTR1A (0.42) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL9585715 | 1.00 | HTR1A (0.42) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL10481283 | 0.84 | HTR1A (0.42) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL10481308 | 0.78 | HSP90AA1 (0.42) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL6350114 | 0.78 | HSP90AA1 (0.47) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL13725104 | 0.77 | HSP90AA1 (0.42) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL6341448 | 0.75 | RAB9A (0.41) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL12211579 | 0.75 | HSP90AA1 (0.40) | HTR1AHSP90AA1RAB9AMEN1KMT2A | |
| SCHEMBL8137807 | 0.75 | CYP1A2 (0.43) | HSP90AA1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL10407545 | 0.75 | HSP90AA1 (0.38) | HTR1AHSP90AA1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194442-A | 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| EP-0360131-A1 | 2,3,4,5-Tetrahydro-1-benzoxepines, method for their preparation, their use and pharmaceutical compositions based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-03-28 | — | — | EP | disclosed |