Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343586 | 0.83 | TDP2 (0.34) | TDP2CRBN | |
| SCHEMBL9590401 | 0.82 | EGFR (0.36) | GAASMN1; SMN2TDP2CRBN | |
| SCHEMBL7483827 | 0.81 | MEN1 (0.36) | GAACRBN | |
| Iodomethane SCHEMBL9590125 | 0.81 | EGFR (0.35) | GAASMN1; SMN2 | |
| SCHEMBL27357288 | 0.77 | TDP2 (0.30) | TDP2CRBN | |
| SCHEMBL7349547 | 0.76 | MAPT (0.49) | TDP2CRBN | |
| SCHEMBL7348992 | 0.75 | ATM (0.50) | GAASMN1; SMN2TDP2 | |
| SCHEMBL7491884 | 0.74 | MMP2 (0.43) | SMN1; SMN2TDP2CRBN | |
| SCHEMBL9588570 | 0.74 | MAPT (0.44) | GAA | |
| SCHEMBL7341257 | 0.74 | SMYD3 (0.33) | TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5081242-A | Cardiotonic and bronchodilator agents; phosphodiesterase inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-01-14 | — | — | US | claimed |
| EP-0272914-A2 | 6-Benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-06-29 | — | — | EP | claimed |
| US-5221742-A | PROCESS FOR THE PREPARATION OF 6-(3,4-DIHYDRO-3-OXO-1,4(2H)-BENZOXAZIN-7-YL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-06-22 | — | — | US | disclosed |