Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.72 |
| ▸ | UBE2M | P61081 | 7/20 | 0.68 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.68 |
| ▸ | CCR2 | P41597 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592024 | 0.88 | DRD4 (0.73) | DRD4SIGMAR1UBE2MDCUN1D1 | |
| SCHEMBL8786936 | 0.86 | DRD4 (1.00) | DRD4SIGMAR1LMNA | |
| SCHEMBL9593263 | 0.84 | DRD4 (0.79) | DRD4SIGMAR1 | |
| SCHEMBL9592418 | 0.84 | DRD4 (0.79) | DRD4SIGMAR1 | |
| SCHEMBL9593089 | 0.84 | DRD4 (0.79) | DRD4SIGMAR1 | |
| SCHEMBL18640301 | 0.81 | DCUN1D1 (1.00) | DRD4SIGMAR1UBE2MDCUN1D1 | |
| SCHEMBL9590922 | 0.81 | DRD4 (0.77) | DRD4SIGMAR1 | |
| Panuramine SCHEMBL2037759 | 0.81 | MCHR1 (0.83) | DRD4SIGMAR1 | |
| SCHEMBL9592321 | 0.81 | DRD4 (0.80) | DRD4SIGMAR1LMNA | |
| SCHEMBL9593042 | 0.81 | DRD4 (0.72) | DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212179-A | Antidepressants | JOHN WYETH AND BROTHER LIMITED (GB) | 1993-05-18 | — | — | US | disclosed |
| US-4985438-A | PSYCHOTROPIC ACTIVITY, ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4806552-A | ANTIDEPRESSANTS | JOHN WYETH & BROTHER, LIMITED (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4722930-A | ANTIDEPRESSANTS | JOHN WYETH AND BROTHER LIMITED (GB) | 1988-02-02 | — | — | US | disclosed |
| US-4563466-A | ANTISEROTONINE | JOHN WYETH & BROTHER LIMITED (GB) | 1986-01-07 | — | — | US | disclosed |
| US-4426387-A | Piperid-4-yl ureas and thio ureas used as anti-depressant agents | JOHN WYETH & BROTHER LTD. (GB) | 1984-01-17 | — | — | US | disclosed |