SCHEMBL959093

SCHEMBL959093

O=c1oc(-c2cc(Cl)nn2-c2ncccc2Cl)nc2c(Cl)cc(I)cc12

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ C1R P00736 3/20 0.33
▸ KLK7 P49862 3/20 0.32
▸ KLK14 Q9P0G3 3/20 0.32
▸ KLK5 Q9Y337 3/20 0.32
▸ CTSG P08311 2/20 0.32
▸ DHODH Q02127 2/20 0.32
▸ PRSS1 P07477 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL959838 0.91 DHODH (0.35) C1RDHODH
SCHEMBL958508 0.87 PIM1 (0.34) C1RKLK7KLK14KLK5CTSG
SCHEMBL31059985 0.85 C1R (0.34) C1RKLK7KLK14KLK5CTSG
SCHEMBL1762432 0.84 CYP17A1 (0.34) C1RDHODH
SCHEMBL31060019 0.83 DHODH (0.34) C1RKLK7KLK14KLK5CTSG
SCHEMBL25082810 0.82 C1R (0.32) C1R
SCHEMBL30389990 0.82 C1R (0.32) C1R
SCHEMBL30466603 0.82 DHODH (0.44) C1RDHODH
SCHEMBL959396 0.82 DHODH (0.44) C1RDHODH
SCHEMBL950708 0.81 KDM4E (0.35) C1RDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9161540-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-20 — — US disclosed
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-25 — — US disclosed
EP-2264022-B1 Cyano anthranilamide insecticides DU PONT (US) 2013-07-24 — — EP disclosed
US-8475819-B2 Cyano anthranilamide insecticides E I DU PONT DE NEMOURS AND COMPANY (US) 2013-07-02 — — US disclosed
EP-1599463-B1 CYANO ANTHRANILAMIDE INSECTICIDES DU PONT (US) 2013-06-05 — — EP disclosed
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-12-29 — — US disclosed
US-7875634-B2 contain 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-pyrazole-5-carboxamide; for controlling invertebrate pests in both agronomic and nonagronomic environments E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-01-25 — — US disclosed
EP-2264022-A1 Cyano anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2010-12-22 — — EP disclosed
US-20070264299-A1 Cyano anthranilamide insecticides FMC CORPORATION 2007-11-15 — — US disclosed
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 — — US disclosed
US-20060111403-A1 Cyano anthranilamide insecticides FMC CORPORATION 2006-05-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060111403-A1 Cyano anthranilamide insecticides C1S, C5, CBR3 C1R 5/4885KLK7 4259/4885KLK14 3841/4885
US-20110319452-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R C1R 3/4885KLK7 4347/4885KLK14 3645/4885
US-20130189228-A1 CYANO ANTHRANILAMIDE INSECTICIDES CBR3, C5, C1R C1R 3/4885KLK7 4347/4885KLK14 3645/4885
US-20070264299-A1 Cyano anthranilamide insecticides C1S, CBR3, C5 C1R 5/4885KLK7 4467/4885KLK14 3687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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