SCHEMBL1762432

SCHEMBL1762432

Cc1cc(Cl)cc2c(=O)oc(-c3cc(Cl)nn3-c3ncccc3Cl)nc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP17A1 P05093 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ DHODH Q02127 2/20 0.34
▸ MAPT P10636 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ MALT1 Q9UDY8 1/20 0.32
▸ TRPV1 Q8NER1 2/20 0.31
▸ ELANE P08246 3/20 0.31
▸ CYP3A4 P08684 3/20 0.31
▸ FABP3 P05413 1/20 0.31
▸ CYP2D6 P10635 1/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ FABP4 P15090 1/20 0.31
▸ FABP5 Q01469 1/20 0.31
▸ PDE10A Q9Y233 2/20 0.30
▸ F2 P00734 1/20 0.30
▸ F10 P00742 1/20 0.30
▸ F7 P08709 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950938 0.92 CYP17A1 (0.34) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL959838 0.91 DHODH (0.35) CYP17A1CYP1A2DHODHMAPTTRPV1
SCHEMBL950829 0.90 DHODH (0.35) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL465839 0.90 DHODH (0.43) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL29598524 0.90 DHODH (0.43) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL951600 0.90 DHODH (0.32) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL950557 0.90 DHODH (0.33) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL25008237 0.89 OPRL1 (0.34) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL951779 0.89 ALDH1A1 (0.33) CYP17A1CYP1A2DHODHMAPTALDH1A1
SCHEMBL12856449 0.89 DHODH (0.33) CYP17A1CYP1A2DHODHMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9445593-B1 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2016-09-20 — — US disclosed
US-20160255835-A1 ARTHROPODICIDAL ANTHRANILAMIDES FMC CORPORATION 2016-09-08 — — US disclosed
US-9173400-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-03 — — US disclosed
US-9113630-B2 Method of controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2015-08-25 — — US disclosed
US-9084422-B2 Anthranilamides compositions E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-21 — — US disclosed
US-9078437-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-14 — — US disclosed
US-9049862-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-06-09 — — US disclosed
US-9049861-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-06-09 — — US disclosed
US-9029365-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-05-12 — — US disclosed
US-8921400-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2014-12-30 — — US disclosed
EP-1427285-B1 ANTHRANILAMIDE ARTHROPODICIDE TREATMENT DU PONT (US) 2007-08-22 — — EP disclosed
US-7232836-B2 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-06-19 — — US disclosed
US-20050215785-A1 Method for preparing fused oxazinones from ortho-amino aromatic carboxylic acid and carboxylic acid in the presence of a sulfonyl chloride and pyridine FMC CORPORATION 2005-09-29 — — US disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 — — US disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 — — US disclosed
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides FMC CORPORATION 2004-10-07 — — US disclosed
EP-1416797-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 — — EP disclosed
EP-1416796-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 — — EP disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 — — WO disclosed
WO-2003015518-A1 METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 CYP17A1 2188/4885CYP1A2 455/4885DHODH 1442/4885
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides CYP4B1, CYP1B1, CYP2E1 CYP17A1 1926/4885CYP1A2 16/4885DHODH 2558/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 CYP17A1 1397/4885CYP1A2 324/4885DHODH 1353/4885
US-20050215785-A1 Method for preparing fused oxazinones from ortho-amino aromatic carboxylic acid and carboxylic acid in the presence of a sulfonyl chloride and pyridine OXGR1, OXSR1, OXER1 CYP17A1 1691/4885CYP1A2 1369/4885DHODH 1363/4885
US-20160255835-A1 ARTHROPODICIDAL ANTHRANILAMIDES ANTXR2, NIT2, NAAA CYP17A1 735/4885CYP1A2 34/4885DHODH 1137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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