Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595308 | 0.93 | KDM1A (0.56) | KDM1AACHEPOLBGAARAD52 | |
| SCHEMBL9595398 | 0.92 | KDM1A (0.51) | KDM1AACHETOP2ATOP2B | |
| SCHEMBL9593869 | 0.92 | KDM1A (0.54) | KDM1APOLBRAD52SMN1; SMN2KMT2A | |
| SCHEMBL9595042 | 0.91 | KDM1A (0.55) | KDM1AACHETOP2ATOP2B | |
| SCHEMBL9594919 | 0.88 | MEN1 (0.46) | KDM1AACHEPOLBGAARAD52 | |
| SCHEMBL9592705 | 0.88 | MEN1 (0.46) | KDM1AACHEPOLBGAARAD52 | |
| SCHEMBL9594083 | 0.87 | KDM1A (0.67) | KDM1ATOP2ATOP2B | |
| SCHEMBL9593811 | 0.86 | TOP2A (0.63) | KDM1AACHETP53SMN1; SMN2KMT2A | |
| SCHEMBL9595381 | 0.85 | HDAC1 (0.54) | KDM1APOLBGAARAD52KMT2A | |
| SCHEMBL9594824 | 0.85 | SLC2A1 (0.48) | KDM1AACHEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |