Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595558 | 0.95 | KDM1A (0.48) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9594205 | 0.95 | KDM1A (0.48) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9593806 | 0.95 | KDM1A (0.54) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9594966 | 0.95 | KDM1A (0.54) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9593647 | 0.94 | KDM1A (0.50) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9593869 | 0.90 | KDM1A (0.54) | KDM1AMAPTPOLBRAD52KMT2A | |
| SCHEMBL9594500 | 0.88 | KDM1A (0.49) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9594824 | 0.88 | SLC2A1 (0.48) | KDM1APDPK1SLC2A1MAP2K1EGFR | |
| SCHEMBL9593866 | 0.87 | TOP2A (0.57) | KDM1ATP53MAPTPOLBPDPK1 | |
| SCHEMBL9594855 | 0.86 | KDM1A (0.47) | KDM1APOLBRAD52SLC2A1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |