Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 14/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 14/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CTSV | O60911 | 1/20 | 0.66 |
| ▸ | CTSL | P07711 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593591 | 0.91 | AKR1C3 (0.79) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL14598926 | 0.90 | AKR1C3 (0.81) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL8773601 | 0.90 | AKR1C3 (0.81) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL9593627 | 0.89 | MEN1 (0.83) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL9594769 | 0.88 | AKR1C3 (0.84) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL22720143 | 0.88 | MEN1 (0.63) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL9593414 | 0.88 | AKR1C3 (0.74) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL1415572 | 0.86 | AKR1C3 (0.82) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL9594435 | 0.85 | AKR1C3 (0.73) | AKR1C3AKR1C2MEN1KMT2ALMNA | |
| SCHEMBL10985308 | 0.84 | MEN1 (0.84) | AKR1C3AKR1C2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |