Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18711805 | 0.89 | POLB (0.65) | POLBCYP3A4CYP2C19LMNAPKM | |
| SCHEMBL14183936 | 0.85 | HDAC8 (0.62) | POLBCYP3A4CYP2C19HDAC8 | |
| SCHEMBL18711811 | 0.85 | POLB (0.61) | POLBCYP3A4CYP2C19LMNAPKM | |
| SCHEMBL9572242 | 0.82 | NPSR1 (0.64) | POLBCYP3A4CYP2C19LMNAHDAC8 | |
| SCHEMBL9572243 | 0.82 | NPSR1 (0.64) | POLBCYP3A4CYP2C19LMNAHDAC8 | |
| SCHEMBL7966652 | 0.81 | POLB (0.59) | POLBCYP3A4CYP2C19LMNATDP1 | |
| SCHEMBL7980018 | 0.81 | POLB (0.59) | POLBCYP3A4CYP2C19LMNATDP1 | |
| SCHEMBL7270113 | 0.80 | POLB (0.56) | POLBCYP3A4CYP2C19LMNAPKM | |
| SCHEMBL12871199 | 0.80 | POLB (0.55) | POLBCYP3A4CYP2C19HDAC8TDP1 | |
| SCHEMBL8908771 | 0.79 | ACE (0.61) | POLBLMNATDP1ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993001174-A1 | THIAZOLIDINE DERIVATIVES AND THEIR USE AS ANTI-VIRAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1993-01-21 | — | — | WO | disclosed |