Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980018 | 1.00 | POLB (0.59) | POLBCYP3A4CYP2C19ACETDP1 | |
| SCHEMBL9596147 | 0.81 | POLB (0.65) | POLBCYP3A4CYP2C19ACETDP1 | |
| SCHEMBL27431292 | 0.80 | NPC1 (0.55) | POLBCYP3A4CYP2C19ACETDP1 | |
| SCHEMBL8538954 | 0.80 | POLB (0.49) | POLBCYP3A4CYP2C19ACE | |
| SCHEMBL8538961 | 0.80 | POLB (0.49) | POLBCYP3A4CYP2C19ACE | |
| SCHEMBL8538958 | 0.80 | POLB (0.49) | POLBCYP3A4CYP2C19ACE | |
| SCHEMBL4113622 | 0.79 | ACE (0.66) | POLBACETDP1L3MBTL1APOBEC3A | |
| SCHEMBL2080858 | 0.79 | ACE (0.59) | POLBACETDP1L3MBTL1CHEK1 | |
| SCHEMBL66872 | 0.79 | ACE (0.59) | POLBACETDP1L3MBTL1CHEK1 | |
| SCHEMBL66871 | 0.79 | ACE (0.59) | POLBACETDP1L3MBTL1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323215-B1 | TREAT AND PREVENT DISORDERS CHARACTERIZED BY NEURONAL DAMAGE SUCH AS PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, STROKE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, DIABETIC NEUROPATHY AND BELL'S PALSY. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-11-27 | — | — | US | disclosed |