Buparvaquone

Buparvaquone

SCHEMBL9598809

CC(C)(C)[C@H]1CC[C@H](CC2=C(O)C(=O)c3ccccc3C2=O)CC1

nearest known ligand 0.82

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.82
APAF1 O14727 2/20 0.41
TDP2 O95551 1/20 0.41
GLA P06280 1/20 0.37
RAB9A P51151 2/20 0.36
POLB P06746 1/20 0.36
ATM Q13315 2/20 0.36
DHODH Q02127 2/20 0.35
MAPT P10636 6/20 0.35
ALDH1A1 P00352 6/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
KMT2A Q03164 3/20 0.35
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 2/20 0.35
TP53 P04637 2/20 0.35
PKM P14618 2/20 0.35
CYP3A4 P08684 1/20 0.35
CDC25A P30304 1/20 0.35
RPS6KA3 P51812 1/20 0.35
GLO1 Q04760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Buparvaquone SCHEMBL22978 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL11030015 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL30634020 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL21863689 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL23064136 0.97 CDC25B (0.79) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL18740425 0.94 CDC25B (0.73) CDC25BAPAF1TDP2GLARAB9A
SCHEMBL28771087 0.90 CDC25B (1.00) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL8200585 0.89 CDC25B (0.66) CDC25BAPAF1TDP2GLARAB9A
SCHEMBL11066443 0.88 CDC25B (0.65) CDC25BAPAF1TDP2RAB9APOLB
SCHEMBL11066448 0.88 CDC25B (0.65) CDC25BAPAF1TDP2RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993020044-A1 1,4 NAPHTHOQUINONE DERIVTIVES WITH ANTI-PROTOZOAL AND ANTI-PARASITIC ACTIVITY THE WELLCOME FOUNDATION LIMITED (GB) 1993-10-14 WO disclosed
EP-0077551-B1 1.4-NAPHTHOQUINONES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL AND VETERINARY FORMULATIONS THEREOF THE WELLCOME FOUNDATION LIMITED (GB) 1985-06-12 EP disclosed
US-4485116-A NAPHTHOQUINONE COMPOUNDS BURROUGHS WELLCOME CO. 1984-11-27 US disclosed
US-4485117-A ANTIMALARIAL AND ANTICOCCIDIAL; HYDROXYNAPHTHOQUINONES BURROUGHS WELLCOME CO., A CORP OF NORTH CAROLINA 1984-11-27 US disclosed
EP-0077550-A2 1.4-Naphthoquinones, methods for their preparation and veterinary formulations thereof THE WELLCOME FOUNDATION LIMITED (GB) 1983-04-27 EP disclosed
EP-0077551-A2 1.4-Naphthoquinones, methods for their preparation, pharmaceutical and veterinary formulations thereof THE WELLCOME FOUNDATION LIMITED (GB) 1983-04-27 EP disclosed