Buparvaquone

Buparvaquone

SCHEMBL21863689

CC(C)(C)C1CCC(CC2=C(O)C(=O)c3ccccc3C2=O)CC1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.82
APAF1 O14727 2/20 0.41
TDP2 O95551 1/20 0.41
GLA P06280 1/20 0.37
RAB9A P51151 2/20 0.36
POLB P06746 1/20 0.36
ATM Q13315 2/20 0.36
DHODH Q02127 2/20 0.35
MAPT P10636 6/20 0.35
ALDH1A1 P00352 6/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
KMT2A Q03164 3/20 0.35
KDM4E B2RXH2 3/20 0.35
MEN1 O00255 2/20 0.35
TP53 P04637 2/20 0.35
PKM P14618 2/20 0.35
CYP3A4 P08684 1/20 0.35
CDC25A P30304 1/20 0.35
RPS6KA3 P51812 1/20 0.35
GLO1 Q04760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Buparvaquone SCHEMBL22978 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL11030015 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL30634020 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL9598809 1.00 CDC25B (0.82) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL23064136 0.97 CDC25B (0.79) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL18740425 0.94 CDC25B (0.73) CDC25BAPAF1TDP2GLARAB9A
SCHEMBL28771087 0.90 CDC25B (1.00) CDC25BAPAF1TDP2GLARAB9A
Buparvaquone SCHEMBL8200585 0.89 CDC25B (0.66) CDC25BAPAF1TDP2GLARAB9A
SCHEMBL11066443 0.88 CDC25B (0.65) CDC25BAPAF1TDP2RAB9APOLB
SCHEMBL11066448 0.88 CDC25B (0.65) CDC25BAPAF1TDP2RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117205190-A Application of buparvaquone in preparation of medicines for resisting Dabiebanda virus infection 中国人民解放军海军军医大学 2023-12-12 CN disclosed
US-20220265566-A1 ATOVAQUONE NANOPARTICULATE COMPOSITIONS TULEX PHARMACEUTICALS INC (US) 2022-08-25 US disclosed
CN-110734368-B Preparation method of buparvaquone 新发药业有限公司 2022-08-12 CN disclosed
US-20220218632-A1 PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2022-07-14 US disclosed
US-11384371-B2 Hydroxylation of branched aliphatic or aromatic substrates employing the amycolatopsis lurida cytochrome P450 HYPHA DISCOVERY LIMITED (GB) 2022-07-12 US disclosed
US-20220144894-A1 ANTIPLASMODIAL COMPOUNDS UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. 2022-05-12 US disclosed
EP-3345594-B1 SOLUBILIZED FLAVONOID COMPOSITION TECH INVESTMENTS LC (US) 2021-11-17 EP disclosed
US-20210230642-A1 HYDROXYLATION TECHNIQUES HYPHA DISCOVERY LTD. (GB) 2021-07-29 US disclosed
US-20210000958-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND VIZURI HEALTH SCIENCES CONSUMER HEALTHCARE, INC. 2021-01-07 US disclosed
US-20200115415-A1 ANTIPLASMODIAL COMPOUNDS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA 2020-04-16 US disclosed
US-20170296668-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND VIZURI HEALTH SCIENCES CONSUMER HEALTHCARE, INC. 2017-10-19 US disclosed
US-20170296668-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND VIZURI HEALTH SCIENCES CONSUMER HEALTHCARE, INC. 2017-10-19 US disclosed
US-9730953-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound VIZURI HEALTH SCIENCES LLC (US) 2017-08-15 US disclosed
US-9730953-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound VIZURI HEALTH SCIENCES LLC (US) 2017-08-15 US disclosed
WO-2017133517-A1 PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF 四川海思科制药有限公司 2017-08-10 WO disclosed
US-20140199391-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND API GENESIS, LLC (US) 2014-07-17 US disclosed
US-20140199391-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND API GENESIS, LLC (US) 2014-07-17 US disclosed
US-8637569-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds API GENESIS, LLC (US) 2014-01-28 US disclosed
US-8637569-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds API GENESIS, LLC (US) 2014-01-28 US disclosed
WO-2012054090-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUNDS API GENESIS, LLC (US) 2012-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220218632-A1 PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF AR, CDK4, PIN1 CDC25B 108/4885APAF1 2489/4885TDP2 2178/4885
US-20220265566-A1 ATOVAQUONE NANOPARTICULATE COMPOSITIONS RECQL, ATIC, POLQ CDC25B 734/4885APAF1 2778/4885TDP2 2874/4885
US-20140199391-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND ABCG2, CYP2F1, LSS CDC25B 1078/4885APAF1 1331/4885TDP2 1188/4885
US-20210000958-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND ABCG2, CYP2F1, LSS CDC25B 1078/4885APAF1 1331/4885TDP2 1188/4885
US-20220144894-A1 ANTIPLASMODIAL COMPOUNDS MGST3, G6PD, GPX4 CDC25B 1978/4885APAF1 627/4885TDP2 1900/4885
US-20170296668-A1 METHODS OF INCREASING SOLUBILITY OF POORLY SOLUBLE COMPOUNDS AND METHODS OF MAKING AND USING FORMULATIONS OF SUCH COMPOUND ABCG2, CYP2F1, LSS CDC25B 1078/4885APAF1 1331/4885TDP2 1188/4885
US-20200115415-A1 ANTIPLASMODIAL COMPOUNDS MGST3, G6PD, GPX4 CDC25B 1978/4885APAF1 627/4885TDP2 1900/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.