Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 3/20 | 0.32 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.32 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9598092 | 0.76 | RAPGEF4 (0.49) | ESR1RAPGEF4HTR6 | |
| SCHEMBL9657015 | 0.76 | HRH3 (0.47) | — | |
| SCHEMBL9599177 | 0.75 | RAPGEF4 (0.41) | ESR1PTGS2RAPGEF4APLNR | |
| SCHEMBL9599556 | 0.74 | KDM4E (0.42) | ESR1LMNAHTTRAPGEF4HTR6 | |
| SCHEMBL9598706 | 0.73 | RAPGEF4 (0.39) | ESR1RAPGEF4HTR6 | |
| SCHEMBL9599595 | 0.71 | RAPGEF4 (0.38) | ESR1PTGS2RAPGEF4APLNR | |
| SCHEMBL9566294 | 0.69 | CA12 (0.44) | PTGS2LMNAHTTHTR6 | |
| SCHEMBL8248875 | 0.69 | ALDH1A1 (0.35) | PTGS2CAMKK1CAMKK2 | |
| SCHEMBL8248942 | 0.67 | HRH3 (0.42) | PTGS2CAMKK1CAMKK2 | |
| SCHEMBL8651607 | 0.67 | GAA (0.42) | ESR1PTGS2LMNARAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |