Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 14/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9599595 | 0.93 | RAPGEF4 (0.38) | APLNRESR1PTGS2RAPGEF4 | |
| SCHEMBL9599177 | 0.90 | RAPGEF4 (0.41) | APLNRESR1PTGS2RAPGEF4 | |
| SCHEMBL9598325 | 0.82 | TSHR (0.41) | PTGS2 | |
| SCHEMBL9597622 | 0.81 | ENPP1 (0.38) | APLNR | |
| Oxalic Acid SCHEMBL9598423 | 0.78 | HRH3 (0.48) | — | |
| SCHEMBL9598092 | 0.78 | RAPGEF4 (0.49) | ESR1RAPGEF4 | |
| Oxalic Acid SCHEMBL9599488 | 0.78 | HRH3 (0.45) | — | |
| Oxalic Acid SCHEMBL9599270 | 0.76 | POLB (0.45) | — | |
| SCHEMBL9598706 | 0.75 | RAPGEF4 (0.39) | ESR1RAPGEF4 | |
| SCHEMBL9597826 | 0.74 | ALK (0.41) | ESR1RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |