Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 10/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812654 | 0.83 | PRKCG (0.50) | PRKCGPRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL2159859 | 0.83 | PRKCG (0.50) | PRKCGPRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL8427694 | 0.82 | PRKCD (0.52) | PRKCGPRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL9812649 | 0.79 | ACE (0.49) | — | |
| SCHEMBL9812655 | 0.79 | ACE (0.49) | — | |
| SCHEMBL8498408 | 0.78 | CAPN1 (0.56) | CAPN1POLBALDH1A1KDM4EALOX15 | |
| SCHEMBL10855534 | 0.78 | CAPN1 (0.56) | CAPN1POLBALDH1A1KDM4EALOX15 | |
| SCHEMBL10854074 | 0.78 | CAPN1 (0.56) | CAPN1POLBALDH1A1KDM4EALOX15 | |
| SCHEMBL3804693 | 0.72 | SMN1; SMN2 (0.47) | CAPN1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL7536950 | 0.70 | ACE (0.49) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238935-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0514851-A1 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5124337-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |