Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11125875 | 0.88 | ALDH1A1 (0.43) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL9601963 | 0.87 | ALDH1A1 (0.43) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL11148451 | 0.84 | NPC1 (0.45) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL9603052 | 0.83 | SCN9A (0.39) | SCN9AALDH1A1NPC1RAB9AADORA2A | |
| SCHEMBL10518997 | 0.81 | ADORA2A (0.42) | SCN9AALDH1A1NPC1RAB9AADORA2A | |
| SCHEMBL9605099 | 0.80 | KCNMA1 (0.49) | ALDH1A1NPC1RAB9AMAPTPOLB | |
| SCHEMBL9601722 | 0.80 | SCN9A (0.45) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL11200589 | 0.76 | NPC1 (0.43) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL11617695 | 0.76 | ALDH1A1 (0.47) | SCN9AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL11208407 | 0.73 | ALDH1A1 (0.45) | ALDH1A1NPC1RAB9AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214004-B1 | 4-OH-QUINOLINE-CARBOXYLIC-ACID DERIVATIVES SUBSTITUTED IN POSITION 2 BY A DIHYDROXY-SUBSTITUTED GROUP, POSSIBLY ETHERIFIED OR ESTERIFIED, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-31 | — | — | EP | claimed |