Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.38 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9601937 | 1.00 | POLB (0.41) | POLBMAPTHTTLMNANQO2 | |
| SCHEMBL9602759 | 0.96 | POLB (0.44) | POLBMAPTHTTLMNADRD2 | |
| Fumaric Acid SCHEMBL10377684 | 0.87 | POLB (0.42) | POLBMAPTHTTLMNADRD2 | |
| Fumaric Acid SCHEMBL10377685 | 0.87 | POLB (0.42) | POLBMAPTHTTLMNADRD2 | |
| SCHEMBL9601411 | 0.86 | LMNA (0.52) | POLBMAPTHTTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9873583 | 0.85 | LMNA (0.52) | POLBMAPTHTTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9603062 | 0.85 | LMNA (0.52) | POLBMAPTHTTLMNAALDH1A1 | |
| SCHEMBL9779635 | 0.83 | LMNA (0.52) | POLBMAPTHTTLMNAALDH1A1 | |
| SCHEMBL10339856 | 0.82 | SMN1; SMN2 (0.53) | POLBMAPTHTTLMNAALDH1A1 | |
| SCHEMBL10375510 | 0.82 | POLB (0.46) | POLBMAPTHTTLMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0311322-B1 | PYRIDINE OR PYRIDAZINE DERIVATIVES AS CARDIO-PROTECTIVE AGENTS AND FOR THE TREATMENT OF ISCHEMIC DISEASE, AND PROCESS FOR THEIR PREPARATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| EP-0311322-A2 | Pyridine or pyridazine derivatives as cardio-protective agents and for the treatment of ischemic disease, and process for their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |