Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | WHR1 | P49842 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593499 | 0.91 | PDE3B (0.46) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9594784 | 0.91 | PDE3B (0.46) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9593886 | 0.91 | PDE3B (0.46) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL11809733 | 0.88 | MAOA (0.60) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9594408 | 0.86 | KDM4E (0.51) | NQO2SMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL9594949 | 0.86 | KDM4E (0.49) | NQO2SMN1; SMN2ALDH1A1KDM4EACHE | |
| SCHEMBL9595219 | 0.86 | TP53 (0.46) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9594424 | 0.86 | LMNA (0.47) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9594269 | 0.83 | NQO2 (0.47) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL9593890 | 0.83 | NQO2 (0.47) | NQO2SMN1; SMN2ALDH1A1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | claimed |
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |