Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602188 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1CD274 | |
| SCHEMBL9601014 | 0.79 | CD274 (0.46) | PTGS2PTGS1CD274 | |
| SCHEMBL5952499 | 0.76 | SCN4A (0.37) | CD274 | |
| SCHEMBL5170477 | 0.73 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL16574098 | 0.73 | MAP4K4 (0.48) | PTGS2PTGS1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL10741025 | 0.72 | PTGS2 (0.47) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL11131311 | 0.70 | PTGS2 (0.41) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL5171324 | 0.70 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL9601318 | 0.70 | AHR (0.43) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9601003 | 0.69 | DPP4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |