Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602073 | 0.79 | PTGS2 (0.42) | CD274PTGS2PTGS1 | |
| SCHEMBL5423580 | 0.74 | GRIA1 (0.44) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL9602188 | 0.74 | PTGS2 (0.43) | CD274PTGS2PTGS1 | |
| SCHEMBL10742738 | 0.73 | MEN1 (0.46) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL28742887 | 0.72 | TNKS2 (0.56) | DPP4 | |
| SCHEMBL5584235 | 0.72 | KMT2A (0.50) | PKM | |
| SCHEMBL30507311 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1CHRNA7HTR7 | |
| SCHEMBL31378249 | 0.71 | PTGS2 (0.46) | CD274PTGS2PTGS1CHRNA7HTR7 | |
| SCHEMBL21317781 | 0.71 | NOS3 (0.41) | CD274PTGS2PTGS1DPP4HTR7 | |
| SCHEMBL28155203 | 0.71 | TP53 (0.38) | CD274TAAR1DPP4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318181-B1 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5169976-A | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0318181-A2 | N-(Biphenylmethyl)-3-hydroxyglutaramic acids and derivatives as hypocholesterolemic agents | PFIZER INC. (US) | 1989-05-31 | — | — | EP | disclosed |