Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.59 |
| ▸ | MTOR | P42345 | 2/20 | 0.59 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.58 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | PRKACG | P22612 | 1/20 | 0.58 |
| ▸ | PRKACB | P22694 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 7/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094879 | 0.84 | PIK3CA (0.58) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL14103869 | 0.82 | RAB9A (0.47) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL14103880 | 0.82 | DHPS (0.43) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL14103871 | 0.82 | PIK3CA (0.42) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL4744102 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL1093085 | 0.80 | PIK3CA (0.49) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL1093962 | 0.80 | PIK3CA (0.57) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL1095288 | 0.80 | PIK3CA (0.57) | PIK3CAMTORPIK3C2BCCNE2PRKACA | |
| SCHEMBL14104064 | 0.79 | CYP1A2 (0.51) | CYP19A1LMNATP53NFKB1RAB9A | |
| SCHEMBL29395996 | 0.79 | CYP1A2 (0.51) | CYP19A1LMNATP53NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812446-B1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LTD (GB) | 2015-11-18 | — | — | EP | disclosed |
| US-7872003-B2 | Pharmaceutical compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2011-01-18 | — | — | US | disclosed |
| US-20080207609-A1 | Pharmaceutical compounds | PLRAMED LIMITED (GB) | 2008-08-28 | — | — | US | disclosed |
| EP-1812446-A1 | PHARMACEUTICAL COMPOUNDS | Piramed Limited (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006046040-A1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LIMITED (GB) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207609-A1 | Pharmaceutical compounds | PIK3CA, JAK2, PIK3R1 | PIK3CA 1/4885MTOR 21/4885PIK3C2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.