Sugi Predict

Sugi Predict / Compounds / SCHEMBL9602762

SCHEMBL9602762

SCHEMBL9602762

CNc1c([N+](=O)[O-])cnc2ccccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.49
▸ MAPT P10636 4/20 0.49
▸ MEN1 O00255 3/20 0.49
▸ MAPK1 P28482 3/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ POLB P06746 2/20 0.47
▸ HTT P42858 2/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ GLA P06280 2/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ LRRK2 Q5S007 1/20 0.41
▸ NCOA1 Q15788 1/20 0.41
▸ NCOA3 Q9Y6Q9 1/20 0.41
▸ ALDH1A1 P00352 3/20 0.41
▸ ABCG2 Q9UNQ0 2/20 0.40
▸ CHRM2 P08172 1/20 0.40
▸ CHRM1 P11229 1/20 0.40
▸ DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9836946 0.84 KMT2A (0.46) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL8726039 0.84 ATM (0.51) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL31411153 0.84 LRRK2 (0.55) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL4700692 0.84 KMT2A (0.46) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL27561395 0.82 MAPT (0.48) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL27091343 0.82 PIN1 (0.46) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL29508380 0.81 MEN1 (0.44) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL22749290 0.81 MEN1 (0.44) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL22749289 0.81 MEN1 (0.44) KMT2AMAPTMEN1MAPK1SMN1; SMN2
SCHEMBL13645413 0.81 MAPT (0.46) KMT2AMAPTMEN1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024080788-A1 NOVEL TRICYCLIC DERIVATIVE COMPOUND AND USES THEREOF 한미약품 주식회사 2024-04-18 — — WO disclosed
US-9567336-B2 Conjugated TLR7 and/or TLR8 and TLR2 agonists INVIVOGEN (FR) 2017-02-14 — — US disclosed
WO-2015082905-A1 IMMUNOGENIC COMPOUND IMMUNE TARGETING SYSTEMS (ITS) LTD (GB) 2015-06-11 — — WO disclosed
EP-0310950-B1 Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes RIKER LABORATORIES, INC. (US) 1993-01-13 — — EP disclosed
EP-0223420-B1 CONDENSED IMIDAZOPYRIDINE DERIVATIVES SHIONOGI & CO., LTD. (JP) 1991-02-27 — — EP disclosed
EP-0145340-B1 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines RIKER LABORATORIES, INC. (US) 1990-01-24 — — EP disclosed
EP-0310950-A1 Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes RIKER LABORATORIES, INC. (US) 1989-04-12 — — EP disclosed
US-4753951-A ANTIDEPRESSANTS, ANXIOLYTICS SHIONOGI & CO., LTD. (JP) 1988-06-28 — — US disclosed
US-4698348-A 1H-imidazo[4,5-c]quinolines and their use as bronchodilating agents RIKER LABORATORIES, INC. (US) 1987-10-06 — — US disclosed
US-4689338-A 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use RIKER LABORATORIES, INC. (US) 1987-08-25 — — US disclosed
EP-0223420-A1 Condensed imidazopyridine derivatives SHIONOGI & CO., LTD. (JP) 1987-05-27 — — EP disclosed
EP-0145340-A2 1H-Imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amines RIKER LABORATORIES, INC. (US) 1985-06-19 — — EP disclosed