Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602165 | 0.91 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2ADRD2 | |
| SCHEMBL9602428 | 0.91 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2ADRD2 | |
| SCHEMBL9602054 | 0.85 | SMN1; SMN2 (0.48) | GAAKMT2ALMNASMN1; SMN2 | |
| SCHEMBL9602093 | 0.83 | HRH3 (0.39) | HRH3MAPK14ALDH1A1GAAKMT2A | |
| SCHEMBL9601997 | 0.83 | HRH3 (0.39) | HRH3MAPK14ALDH1A1GAAKMT2A | |
| SCHEMBL9601550 | 0.82 | HRH3 (0.40) | HRH3MAPK14ALDH1A1GAAKMT2A | |
| SCHEMBL9873107 | 0.81 | HRH3 (0.38) | HRH3MAPK14ALDH1A1GAAKMT2A | |
| Iodide SCHEMBL10445026 | 0.81 | HRH3 (0.37) | HRH3MAPK14ALDH1A1GAAKMT2A | |
| SCHEMBL9602957 | 0.79 | PTGS1 (0.42) | KMT2ALMNASLC6A2 | |
| SCHEMBL9603116 | 0.79 | CYP2D6 (0.41) | MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |