Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601997 | 0.92 | HRH3 (0.39) | HRH3ALDH1A1GAAKMT2ANR3C1 | |
| SCHEMBL9602093 | 0.86 | HRH3 (0.39) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9602957 | 0.86 | PTGS1 (0.42) | KMT2A | |
| SCHEMBL9867239 | 0.86 | HRH3 (0.39) | HRH3DRD2MCHR1 | |
| SCHEMBL9602165 | 0.85 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2ADRD2 | |
| Fumaric Acid SCHEMBL9866109 | 0.85 | HRH3 (0.37) | HRH3ALDH1A1GAAKMT2ANR3C1 | |
| SCHEMBL9873107 | 0.84 | HRH3 (0.38) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9602428 | 0.84 | HRH3 (0.41) | HRH3ALDH1A1GAAKMT2ADRD2 | |
| Iodide SCHEMBL10445026 | 0.84 | HRH3 (0.37) | HRH3ALDH1A1GAAKMT2AMAPK14 | |
| SCHEMBL9602367 | 0.83 | ATM (0.47) | KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |