Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272660 | 0.80 | ALDH1A1 (0.48) | ALDH1A1NPC1MEN1RAB9AKMT2A | |
| SCHEMBL9602997 | 0.78 | KCNH3 (0.43) | ALDH1A1LMNAHTTNPC1MEN1 | |
| SCHEMBL30593321 | 0.77 | TLR8 (0.48) | ALDH1A1NPC1CYP2C19TSHR | |
| SCHEMBL24567768 | 0.77 | TLR8 (0.48) | ALDH1A1NPC1CYP2C19TSHR | |
| SCHEMBL146979 | 0.75 | CYP2C19 (0.39) | ALDH1A1LMNAHTTNPC1MEN1 | |
| Isaxonine SCHEMBL1270289 | 0.74 | KCNH3 (0.43) | ALDH1A1LMNAHTTMEN1KMT2A | |
| SCHEMBL10125355 | 0.70 | CYP2C19 (0.39) | ALDH1A1LMNAHTTNPC1MEN1 | |
| SCHEMBL13736558 | 0.70 | IDH1 (0.41) | ALDH1A1LMNAHTTCYP2C19FFAR2 | |
| SCHEMBL10154754 | 0.70 | IDH1 (0.41) | ALDH1A1LMNAHTTCYP2C19FFAR2 | |
| SCHEMBL1905978 | 0.70 | CYP2C19 (0.39) | ALDH1A1LMNAHTTNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232623-B1 | 1-CARBACEPHALOSPORIN ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4892942-A | 1-CARBA (DETHIA)CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1990-01-09 | — | — | US | disclosed |
| US-4791106-A | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0232623-A1 | 1-Carbacephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1987-08-19 | — | — | EP | disclosed |