Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | RAD52 | P43351 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595420 | 0.89 | KDM1A (0.60) | KDM1APOLBRAD52RAB9AGAA | |
| SCHEMBL13692586 | 0.81 | KDM1A (0.58) | KDM1APOLBRAD52RAB9AGAA | |
| SCHEMBL9594810 | 0.76 | TOP2A (0.55) | KDM1APOLBRAD52RAB9AKDM4E | |
| SCHEMBL9603150 | 0.75 | HDAC3 (0.67) | KDM1APOLBRAD52KDM4EMITF | |
| SCHEMBL4939495 | 0.75 | MEN1 (0.67) | KDM1APOLBRAD52RAB9AGAA | |
| SCHEMBL9594846 | 0.74 | KMT2A (0.62) | KDM1APOLBRAD52RAB9AGAA | |
| SCHEMBL28549525 | 0.74 | FABP4 (0.47) | RAB9AGAAKDM4EALDH1A1LMNA | |
| SCHEMBL9594009 | 0.74 | TOP2A (0.49) | KDM1APOLBRAD52RAB9AKDM4E | |
| SCHEMBL23630584 | 0.73 | KDM1A (0.78) | KDM1APOLBRAD52RAB9AGAA | |
| SCHEMBL15673424 | 0.73 | KDM1A (0.66) | KDM1APOLBRAD52RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229395-A | Potential anticancer agents derived from acridine | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1991005770-A1 | POTENTIAL ANTICANCER AGENTS DERIVED FROM ACRIDINE | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-05-02 | — | — | WO | disclosed |