SCHEMBL9603597

SCHEMBL9603597

Cc1cc(Oc2ccc(N=C=O)cc2)ccc1N=C=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.53
TRPA1 O75762 1/20 0.53
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
HPGD P15428 2/20 0.39
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 1/20 0.36
GFER P55789 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP1A2 P05177 1/20 0.33
FURIN P09958 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
ACACB O00763 1/20 0.31
ACACA Q13085 1/20 0.31
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11785119 0.87 CYP3A4 (0.42) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL8567728 0.83 CYP3A4 (0.49) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL10341851 0.83 CYP3A4 (0.49) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL10341870 0.82 CYP3A4 (0.47) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL77895 0.81 CYP3A4 (0.71) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL29373346 0.81 CYP3A4 (0.71) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL50333 0.80 CYP3A4 (0.54) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL4551613 0.80 CYP3A4 (0.54) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL4544188 0.80 CYP3A4 (0.54) CYP3A4TRPA1ALDH1A1TDP1HPGD
SCHEMBL10536307 0.80 TRPA1 (0.45) CYP3A4TRPA1ALDH1A1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5339226-A None JP disclosed
JP-H05339226-A NOVEL DIPHENYL ETHER-BASED DIISOCYANATE MITSUI TOATSU CHEM INC 1993-12-21 JP disclosed